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Sensitive Biological Detection with a Soluble and Stable Polymeric Paramagnetic Nanocluster.
- Source :
-
Journal of the American Chemical Society . 6/27/2012, Vol. 134 Issue 25, p10377-10380. 4p. - Publication Year :
- 2012
-
Abstract
- We describe the design, synthesis, and biological characterization of manganese oxocluster-based "single molecule magnets (SMMs)". We demonstrate that polymeric micellar nanoparticles can serve as a carrier and help to stabilize delicate SMM molecules from breaking down easily and thus prevent their property loss. Concentrating thousands of Mn-clusters per micelle provided a high ionic and per-particle relaxivity allowing sensitive MR imaging in vivo. This reports one of the earliest examples of in vivo imaging of a rationally designed polymeric micelle that features SMM. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 134
- Issue :
- 25
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 77605171
- Full Text :
- https://doi.org/10.1021/ja3040366