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Highly potent inhibitors of TNF-α production. Part 2: identification of drug candidates
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Mar2002, Vol. 12 Issue 6, p907. 4p. - Publication Year :
- 2002
-
Abstract
- Metabolic stabilization of the chemical lead 1, which is a structurally novel inhibitor of TNF-α production, was accomplished by introducing a (1S)-methyl group into the optically active backbone. As a result, 2, 3 and 4 were identified as drug candidates and evaluated pharmacologically. The analysis of an active conformer was also carried out. [Copyright &y& Elsevier]
- Subjects :
- *METHYL groups
*PHARMACOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 12
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7761377
- Full Text :
- https://doi.org/10.1016/S0960-894X(02)00037-9