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Kinetics and mechanism of formation of [Fe(CN)5INH]3- by ligand substitution in acidic media (INH = isoniazid).
- Source :
-
Progress in Reaction Kinetics & Mechanism . Sep2012, Vol. 37 Issue 3, p291-300. 10p. 2 Diagrams, 3 Charts, 3 Graphs. - Publication Year :
- 2012
-
Abstract
- The kinetics and mechanism of formation of [Fe(CN)5INH]3- by a ligand substitution reaction between aquapentacyanoferrate(II) ion and isoniazid, (pyridine-4-carboxylic acid hydrazide) (INH) have been investigated spectrophotometrically in acidic media at 435 nm ( lmax of product), under pseudo-first order conditions, using excess of INH over [Fe(CN)5H2O]3-. The reaction was studied as a function of [Fe(CN)5 H2O3-], [INH], pH, ionic strength and temperature, by varying only one of these variables while other variables were held constant. The reaction exhibited first-order kinetics in [INH] while it was independent of [Fe(CN)5H2O3-] in the chosen concentration range. The effect of temperature on the reaction rate yielded the activation parameters. The most plausible mechanism consistent with the experimental results has been proposed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14686783
- Volume :
- 37
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Progress in Reaction Kinetics & Mechanism
- Publication Type :
- Academic Journal
- Accession number :
- 77738933
- Full Text :
- https://doi.org/10.3184/146867812X13330249167431