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Specificity of a heme-assimilating system of Vibrio vulnificus to synthetic heme compounds
- Source :
-
FEMS Microbiology Letters . Feb2002, Vol. 208 Issue 1, p77. 5p. - Publication Year :
- 2002
-
Abstract
- Vibrio vulnificus strain L-180, a clinical isolate, can obtain iron from a synthetic heme, iron–tetra(4-sulfonatophenyl)porphyrin (Fe–TPPS), as well as from a natural heme, protoheme. This assimilation of iron bound to TPPS was demonstrated to be a common property of V. vulnificus by testing a total of 27 strains isolated from both clinical and environmental sources. Strain L-180 could also utilize Fe–TCPP, but not Fe–TMPyP, as a sole iron source. TPPS or its complex with a metal ion reduced bacterial multiplication in the broth containing a minimum dose of Fe–TPPS. When inoculated into human serum supplemented with Fe–TCPP, L-180 could grow only in the presence of a protease from the same bacterium. In both TPPS and TCPP, each side chain of a porphyrin ring has a negative charge. Therefore, this negative charge may be important for interaction with an outer membrane receptor involving in a heme-assimilating system of V. vulnificus. [Copyright &y& Elsevier]
- Subjects :
- *HEME
*PORPHYRINS
Subjects
Details
- Language :
- English
- ISSN :
- 03781097
- Volume :
- 208
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- FEMS Microbiology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7775987
- Full Text :
- https://doi.org/10.1111/j.1574-6968.2002.tb11063.x