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Intra-abdominal Clear-Cell Sarcoma: A Report of 3 Cases, Including 1 Case With Unusual Morphological Features, and Review of the Literature.
- Source :
-
International Journal of Surgical Pathology . Aug2012, Vol. 20 Issue 4, p378-385. 8p. - Publication Year :
- 2012
-
Abstract
- Clear-cell sarcoma (CCS) is a soft-tissue neoplasm that morphologically resembles cutaneous malignant melanoma but has a distinct molecular profile. Gastrointestinal and intra-abdominal CCSs are very rare. Here, the authors present 3 cases of intra-abdominal CCS and review the literature. Of these cases, 2 involved the small bowel, and 1 involved the peritoneum. Cases 1 and 3 had the characteristic CCS morphology, but case 2 was morphologically unusual and therefore difficult to diagnose. It had relatively small cells with less prominence of clear cells; many pseudoglandular structures were also present. It also showed aberrant expression of epithelial membrane antigen (EMA). The other 2 cases also involved some diagnostic uncertainty and were therefore referred to specialized centers. The authors wish to emphasize the importance of molecular studies in making a conclusive diagnosis of intra-abdominal CCS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10668969
- Volume :
- 20
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Surgical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 77761383
- Full Text :
- https://doi.org/10.1177/1066896911425485