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Observations on chemical and enzymatic approaches to α-2,3-sialylated octyl β-lactoside
- Source :
-
Tetrahedron . Apr2002, Vol. 58 Issue 16, p3207. 10p. - Publication Year :
- 2002
-
Abstract
- A comparison of chemical and chemo-enzymatic syntheses of α-2,3-sialylated octyl lactoside is reported. The chemical approach, starting from lactose and sialic acid, required 14 steps and proceeded in 5% overall yield; poor α-selectivity in the sialylation step necessitated a difficult and low yielding separation of anomers. A chemoenzymatic approach, employing recombinant Trypanosoma cruzi trans-sialidase to effect the key sialylation reaction, required 10 steps and gave a similar overall yield. Whereas the chemo-enzymatic synthesis required only three chromatographic purification steps overall, the chemical synthesis required at least nine. [Copyright &y& Elsevier]
- Subjects :
- *NEURAMINIDASE
*BIOSYNTHESIS
Subjects
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 58
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 7779747
- Full Text :
- https://doi.org/10.1016/S0040-4020(02)00265-X