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The Effects of Gender and Gonadal Steroids on the Neuroendocrine and Temperature Response to m-Chlorophenylpiperazine in Leuprolide-induced Hypogonadism in Women and Men
- Source :
-
Neuropsychopharmacology . Nov2002, Vol. 27 Issue 5, p800. 13p. - Publication Year :
- 2002
-
Abstract
- Studies of the effects of gender and gonadal steroids on serotonergic activity in humans are few in number and often contradictory. We examined the neuroendocrine and core temperature response to a serotonergic stimulus, m-chlorophenylpiperazine (m-CPP) (0.08 mg/kg body weight, IV), in asymptomatic female and male volunteers during induced hypogonadism (leuprolide acetate) and hormone replacement (estradiol (E2) or progesterone (P4) in women; testosterone (T) in men).Compared with the hypogonadal state, basal prolactin (PRL) secretion was significantly higher during both P4 and E2 replacement (p < .05) in women and during T replacement in men (p < .05). m-CPP stimulated PRL secretion was significantly greater only during P4 (p < .05) but not E2 (women) or T (men) replacement, compared with hypogonadism. Basal but not stimulated plasma growth hormone (GH) levels were significantly higher during P4 in women and T in men (p < .05), and no significant differences in basal or m-CPP stimulated plasma levels of ACTH or cortisol were observed. Finally, basal core temperatures were significantly higher during P4 replacement compared with either E2 replacement or the hypogonadal condition (p < .01) in women, with no differences observed in men. Comparisons of measures by gender (and matched for baseline plasma T levels) revealed that during the hypogonadal state m-CPP–stimulated GH secretion was significantly greater (p < .01) and m-CPP–stimulated ACTH (p < .05) and cortisol (p < .01) significantly less in women compared with men.Although our data are limited to those components of the central serotonergic system influenced by m-CPP administration, our findings suggest the following: the regulatory effects of gonadal steroids on serotonergic function are modest in humans during leuprolide-induced hypogonadism; menstrual cycle phase effects of serotonergic agents on PRL secretion may reflect both the effects of P4 and E2; the effects of P4 in humans may occur without E2 priming of the progesterone receptor; and gender differences in GH secretion occur independent of the presence of gonadal steroids. [Copyright &y& Elsevier]
- Subjects :
- *NEUROENDOCRINOLOGY
*SEROTONINERGIC mechanisms
*PROGESTERONE
*TESTOSTERONE
Subjects
Details
- Language :
- English
- ISSN :
- 0893133X
- Volume :
- 27
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7789108
- Full Text :
- https://doi.org/10.1016/S0893-133X(02)00334-2