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Clinical Signs, Hospitalization Duration and Outcome of Tramadol Intoxication.
- Source :
-
Journal of Isfahan Medical School . 2/7/2011, Vol. 28 Issue 117, p1-7. 7p. - Publication Year :
- 2011
-
Abstract
- Background: Regarding increasing tramadol toxicity in recent years due to usage of tramadol as a drug for suppression of withdrawal symptoms and high availability of this drug, we did a survey on the frequency of tramadol intoxication symptoms, duration of admission, therapeutic measurements, tramadol dosage, and prognosis of the patients. Methods: We conducted a cross sectional study, in which information of every patient with tramadol toxicity admitted in Noor hospital ward of toxicology (Isfahan, Iran) were gathered and analyzed. Finding: From 184 cases, 141 (76.6%) were men. The mean age of the patients was 24 ± 7 years. Forty percent of patient had positive history of substance abuse. Eighty four cases (45.6%) were with coingestion. Thirty four percent of patients had chronic ingestion of tramadol. The most common chief complaint was central nervous system (CNS) depression (57%) followed by seizure (25%), bradypnea (18%), tachycardia (25%), and hypertension (7%). Active charcol (89%), gastric lavage (81%), naloxane (25%), anti convulsants (11%), and intubation and ventilation (5%) were done as therapeutic acts. The most common complication in patients was aspiration pneumonia. Two (1.1%) patients died. There were significant relationships between tramadol dose and seizure (P = 0.036), ataxia (P = 0.002), and outcome (P < 0.001). Conclusion: Tramadol overdose frequently cause CNS depression, respiratory depression, tachycardia, hypertension, and seizure; these symptoms could be from both effects of tramadol either on mu receptor or inhibition of monoamine reuptake. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TRAMADOL
*DRUG withdrawal symptoms
*DRUG toxicity
*HYPERTENSION
*MENTAL depression
Subjects
Details
- Language :
- Persian
- ISSN :
- 10277595
- Volume :
- 28
- Issue :
- 117
- Database :
- Academic Search Index
- Journal :
- Journal of Isfahan Medical School
- Publication Type :
- Academic Journal
- Accession number :
- 77916072