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Regulation of ROMK Channels by Protein Tyrosine Kinase and Tyrosine Phosphatase
- Source :
-
Trends in Cardiovascular Medicine . Apr2002, Vol. 12 Issue 3, p138-142. 5p. - Publication Year :
- 2002
-
Abstract
- Renal outer medulla K (ROMK) channels play an important role in K recycling in the thick ascending limb and in K secretion in the cortical collecting duct. ROMK1, a member of the ROMK family, has been shown to be a substrate for protein tyrosine kinase (PTK). The tyrosine phosphorylation of ROMK channels increases with low dietary K intake and decreases with high dietary K intake. Moreover, the stimulation of tyrosine phosphorylation of ROMK1 channels decreases the number of K channels by facilitating endocytosis. In contrast, the stimulation of tyrosine dephosphorylation increases the number of ROMK1 channels in the cell membrane by enhancing membrane insertion. PTK and tyrosine phosphatase-induced regulation of ROMK1 channels play a key role in mediating the effect of the dietary K intake on renal K secretion. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 10501738
- Volume :
- 12
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Trends in Cardiovascular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 7801465
- Full Text :
- https://doi.org/10.1016/S1050-1738(02)00155-X