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Synthesis of 3-Substituted Isocoumarins via a Cascade Intramolecular Ullmann-Type Coupling-Rearrangement Process.
- Source :
-
Journal of Organic Chemistry . 7/6/2012, Vol. 77 Issue 13, p5736-5743. 8p. - Publication Year :
- 2012
-
Abstract
- A simple and highly efficient strategy for the synthesis of 3-substituted isocoumarins through a copper(I)-catalyzed reaction of 1-(2-halophenyl)-1,3-diones has been developed. The procedure is based on a cascade copper-catalyzed intramolecular Ullmann-type C-arylation and rearrangement process. This methodology is tolerant of a wide range of substrates and applicable to library synthesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ISOCOUMARINS
*ORGANIC synthesis
*ARYLATION
*COPPER
*CHEMICAL reactions
Subjects
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 77
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 78023164
- Full Text :
- https://doi.org/10.1021/jo300916s