Mutation in the THPO gene is not associated with aplastic anaemia in Japanese children.

The article informs that mutation in THPO gene which encodes thrombopoietin is not associated with Aplastic Anaemia (AA). It mentions that THPO is the causative gene for congenital amegakaryocytic thrombocytopenia (CAMT). It further mentions that for the determination of THPO association, the gene sequence consisting of 12 exons were analyzed and these exons were amplified by polymerase chain reaction of genomic DNA from patients with AA. It concludes that no THPO mutations were found.