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Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives.
- Source :
-
Molecules . Jul2012, Vol. 17 Issue 7, p8674-8686. 13p. 3 Diagrams, 4 Charts. - Publication Year :
- 2012
-
Abstract
- A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For comparison the reactions were carried out under both conventional and ultrasonic conditions. In general, improvement in rates and yields were observed when the reactions were carried out under sonication compared with classical conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARBOHYDRATES
*PIPERIDINE
*SONICATION
*ISATIN
*MALONONITRILE
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 17
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 78363008
- Full Text :
- https://doi.org/10.3390/molecules17078674