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Apelin-immunoreactivity in the rat hypothalamus and pituitary
- Source :
-
Neuroscience Letters . Jul2002, Vol. 327 Issue 3, p193. 5p. - Publication Year :
- 2002
-
Abstract
- With the use of an antiserum against human apelin-36, apelin-immunoreactivity (irAP) was detected in neurons and cell processes of the supraoptic nucleus (SO), paraventricular nucleus (PVH), accessory neurosecretory nuclei (Acc) and suprachiasmatic nucleus. Strongly labeled cells/processes were noted in the internal layer of the median eminence, infundibular stem, anterior and posterior pituitary. Double-labeling the sections with goat polyclonal neurophysin I-antiserum and rabbit polyclonal apelin-antiserum revealed a population of magnocellular neurons in the PVH, SO and Acc expressing both irAP and neurophysin I-immunoreactivity (irNP), the latter being a marker of oxytocin-containing neurons. By inference, the AP-positive but irNP-negative magnocellular neurons could be vasopressin-containing. The presence of irAP in certain hypothalamic nuclei and pituitary suggests that the peptide may be a signaling molecule released from the hypothalamic-hypophysial axis. [Copyright &y& Elsevier]
- Subjects :
- *OXYTOCIN
*NEURONS
*SUPRAOPTIC nucleus
*NERVOUS system
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 327
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7839122
- Full Text :
- https://doi.org/10.1016/S0304-3940(02)00411-1