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Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-Resistant viral strains
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Sep2002, Vol. 12 Issue 17, p2419. 4p. - Publication Year :
- 2002
-
Abstract
- Indinavir analogues with blocked metabolism sites show highly improved pharmacokinetic profiles in animals. The cis-aminochromanol substituted analogues exhibited excellent potency against both the wild-type (NL4-3) virus and protease inhibitor-resistant HIV strains. [Copyright &y& Elsevier]
- Subjects :
- *PHARMACOKINETICS
*PROTEASE inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 12
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7854458
- Full Text :
- https://doi.org/10.1016/S0960-894X(02)00424-9