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Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers

Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers

Authors :
Colosio, Claudio
Fustinoni, S.
Birindelli, S.
Bonomi, I.
De Paschale, G.
Mammone, T.
Tiramani, M.
Vercelli, F.
Visentin, S.
Maroni, M.
Source :
Toxicology Letters. Aug2002, Vol. 134 Issue 1-3, p133. 8p.
Publication Year :
2002

Abstract

In the present study, the personal exposure to mancozeb and/or ethilenethiourea (ETU) in 13 Italian vineyard workers and in 13 subjects without occupational exposure to pesticides was investigated. With this aim, the level of ETU in urine and the dermal exposure to mancozeb were determined. Baseline urinary ETU results were lower than the analytical limit of detection for all controls (<0.5 μg/g creatinine) and for ten workers (median <0.5, range <0.5–3.4 μg/g creatinine). In workers, urinary ETU was significantly increased at the end of shift (2.5, <0.5–95.2 μg/g creatinine) compared with baseline levels. End-shift urinary ETU was higher in operators using open tractors (n=7) than in those using closed tractors (n=5) (16.2 vs. 2.4 μg/g creatinine), but the difference was not significant (P=0.073). End-shift urinary ETU was positively correlated with dermal exposure to mancozeb determined both over the clothes and on the skin (Spearman''s ρ=0.770 and 0.702, P=0.009 and 0.024, respectively). Wine consumption positively influenced the excretion of ETU. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
03784274
Volume :
134
Issue :
1-3
Database :
Academic Search Index
Journal :
Toxicology Letters
Publication Type :
Academic Journal
Accession number :
7861566
Full Text :
https://doi.org/10.1016/S0378-4274(02)00182-0