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LaPSvS1, a (1→3)-β-galactan sulfate and its effect on angiogenesis in vivo and in vitro
- Source :
-
Carbohydrate Research . Sep2002, Vol. 337 Issue 16, p1459. 8p. - Publication Year :
- 2002
-
Abstract
- LaPSvS1, a highly sulfated branched (1→3)-β-galactan was prepared from the arabino-galactan from Larix decidua Miller by partial hydrolysis and subsequent sulfation with SO3-pyridine in DMF. The molecular weight was analyzed by GPC and the sulfate content was determined by ion chromatography. LaPSvS1 exhibited good antiangiogenic and antiinflammatory effects in two different modifications of the known CAM-assay. In vitro results obtained in the FGF-2-trypsin-assay and in fluorospectrometric experiments revealed that LaPSvS1 interacts with the fibroblast growth factor 2 system. This interaction is correlated with the in vivo effect of LaPSvS1 on FGF-2 induced angiogenesis. [Copyright &y& Elsevier]
- Subjects :
- *GALACTANS
*ARABINOGALACTAN
*EUROPEAN larch
Subjects
Details
- Language :
- English
- ISSN :
- 00086215
- Volume :
- 337
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Carbohydrate Research
- Publication Type :
- Academic Journal
- Accession number :
- 7864718