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Effects of electrical stimulation of the inferior colliculus on 2f1−f2 distortion product otoacoustic emissions in anesthetized guinea pigs
- Source :
-
Hearing Research . Aug2002, Vol. 170 Issue 1/2, p116. 11p. - Publication Year :
- 2002
-
Abstract
- The effects of electrical stimulation of the inferior colliculus (IC) on the activation of olivocochlear nerve fibers were investigated in guinea pigs in which the 2f1−f2 distortion product otoacoustic emissions (DPOAE) were recorded. Animals were anesthetized with ketamine (33 mg/kg) and xylazine (6.6 mg/kg). Bipolar electrical stimulation of the IC by a train of pulses with currents less than the threshold for evoking muscle twitches resulted in a small depression of the DPOAE amplitude by 0.1–2 dB. The maximal effect was observed when the stimulating electrodes were located in the rostro-medial or ventral parts of the IC. The suppression of electrically evoked DPOAE was similar to the DPOAE suppression produced by acoustical stimulation of the contralateral ear by a broad-band noise. Suppression of DPOAE amplitude in response to both acoustical and electrical stimulation was abolished 1–2 h after a single intramuscular injection of gentamicin (210–250 mg/kg). The results indicate that electrical stimulation of the IC can activate the efferent system and produce DPOAE changes by similar mechanisms as does acoustical stimulation of the contralateral ear. [Copyright &y& Elsevier]
- Subjects :
- *INFERIOR colliculus
*ELECTRIC stimulation
*OTOACOUSTIC emissions
Subjects
Details
- Language :
- English
- ISSN :
- 03785955
- Volume :
- 170
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Hearing Research
- Publication Type :
- Academic Journal
- Accession number :
- 7870080
- Full Text :
- https://doi.org/10.1016/S0378-5955(02)00397-0