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A phosphodiesterase inhibitor, pentoxifylline, enhances the bone morphogenetic protein-4 (BMP-4)-dependent differentiation of osteoprogenitor cells
- Source :
-
BONE . Sep2002, Vol. 31 Issue 3, p396. 6p. - Publication Year :
- 2002
-
Abstract
- Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-β superfamily, is capable of initiating differentiation of uncommitted mesenchymal cells into a chondro/osteogenic pathway. This study reports the effects of pentoxifylline (PTX), a nonspecific inhibitor of phosphodiesterases (PDEs), that causes elevation of the intracellular cyclic adenosine monophosphate (cAMP) level on the BMP-4-induced chondro/osteogenic differentiation of a mesenchymal cell line, C3H10T1/2; a bone marrow stromal cell line, ST2; and an osteoblastic cell line, MC3T3-E1. It was found that PTX enhanced BMP-4-induced chondro/osteogenic differentiation in C3H10T1/2 and ST2 cells. Similar effects were observed when adding dibutyryl-cAMP and forskolin. These results indicate that cAMP may potentiate the action of BMP-4 on osteoprogenitor cells, highlighting the possibility that PDE inhibitors could be used as therapeutic agents to enhance bone formation through this effect. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 87563282
- Volume :
- 31
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- BONE
- Publication Type :
- Academic Journal
- Accession number :
- 7875047
- Full Text :
- https://doi.org/10.1016/S8756-3282(02)00839-6