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Nucleic acid aptamers in cancer medicine
- Source :
-
FEBS Letters . Sep2002, Vol. 528 Issue 1-3, p12. 5p. - Publication Year :
- 2002
-
Abstract
- Many signalling proteins involved in diverse functions such as cell growth and differentiation can act as oncogenes and cause cellular transformation. These molecules represent attractive targets for cancer diagnosis or therapy and are therefore subject to intensive investigation. Aptamers are small nucleic acid molecules, isolated from combinatorial libraries by a procedure termed SELEX, that bind to a target molecule by providing a limited number of specific contact points embedded in a larger, defined three-dimensional structure. In some cases aptamers have the potential to inhibit the biological function of the molecule resulting in useful reagents for target validation in a variety of disease models. [Copyright &y& Elsevier]
- Subjects :
- *NUCLEIC acids
*CANCER treatment
*VASCULAR endothelium
*GROWTH factors
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 528
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7882012
- Full Text :
- https://doi.org/10.1016/S0014-5793(02)03275-1