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Development of a Universal Colorimetric Indicator for G-Quadruplex Structures by the Fusion of Thiazole Orange and Isaindigotone Skeleton.
- Source :
-
Analytical Chemistry . 8/7/2012, Vol. 84 Issue 15, p6288-292. 5p. - Publication Year :
- 2012
-
Abstract
- The rapid and convenient method for identification of all kinds of G-quadruplex is highly desirable. In the present study, a novel colorimetric indicator for a vast variety of G-quadruplex was designed and synthesized on the basis of thiazole orange and isaindigotone skeleton. Its distinct color change enables label-free visual detection of G-quadruplexes, which is due to the disassembly of dye H-aggregates to monomers. This specific detection of G-quadruplex arises from its end-stacking interaction with G-quartet. On the basis of this universal indicator, a facile approach for large-scale identification of G-quadruplex was developed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00032700
- Volume :
- 84
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Analytical Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 78949705
- Full Text :
- https://doi.org/10.1021/ac300207r