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Highly potent inhibitors of TNF-α production. Part I: Discovery of new chemical leads and Their structure–Activity relationships
- Source :
-
Bioorganic & Medicinal Chemistry . Dec2002, Vol. 10 Issue 12, p3757. 30p. - Publication Year :
- 2002
-
Abstract
- Discovery of new chemical leads of inhibitors for TNF-α production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-α expression in the liver and spleen of mice. Structure–activity relationships (SARs) are also discussed and full details including the chemistry are reported. [Copyright &y& Elsevier]
- Subjects :
- *TUMOR necrosis factors
*CHEMICAL inhibitors
*STRUCTURE-activity relationships
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 10
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 7908584
- Full Text :
- https://doi.org/10.1016/S0968-0896(02)00381-4