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Discovery of Novel Phosphonic Acid Derivatives as New Chemical Leads for Inhibitors of TNF-α production
- Source :
-
Bioorganic & Medicinal Chemistry . Dec2002, Vol. 10 Issue 12, p3807. 9p. - Publication Year :
- 2002
-
Abstract
- 2-(Acylamino)benzylphosphonic acid 6 derived from an artificial substrate of sphingomyelinase was found to show inhibitory activity of TNF-α production. Structural optimization was started with the chemical modification of 6. The discovery of another chemical leads 7, 8, 10 and 16 for the development of structurally new inhibitors of TNF-α production is reported. [Copyright &y& Elsevier]
- Subjects :
- *PHOSPHONIC acids
*TUMOR necrosis factors
*CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 10
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 7908589
- Full Text :
- https://doi.org/10.1016/S0968-0896(02)00343-7