Association between interleukin-10 gene −592 C/A polymorphism and the risk of type 2 diabetes mellitus: A meta-analysis of 5320 subjects

Abstract: Increasing evidence suggests that interleukin-10 (IL-10) gene −592 C/A polymorphism may be associated with an increased risk of type 2 diabetes mellitus (T2DM). To provide a quantitative assessment of the association between this variant and risk of T2DM, we performed this meta-analysis. Systematic searches of electronic databases PubMed, Embase, Web of Science, CBMdisc and CNKI, as well as hand searching of the references of identified articles were performed. A total of 2698 T2DM cases and 2622 controls in seven case–control studies were included in this meta-analysis. The results showed no evidence for significant association between IL-10 gene −592 C/A polymorphism and T2DM risk (for A allele vs. C allele: OR=0.94, 95% CI=0.69–1.29, p =0.69; for A/A vs. C/C: OR=0.88, 95% CI=0.39–1.98, p =0.75; for A/A vs. A/C+C/C: OR=1.04, 95% CI=0.59–1.82, p =0.89; for A/A+A/C vs. C/C: OR=1.11, 95% CI=0.73–1.69, p =0.61). In addition, the similar results were obtained in the subgroup analysis based on the ethnicity. In summary, results from this meta-analysis suggest that the IL-10 gene −592 C/A polymorphism is not associated with T2DM risk. [Copyright &y& Elsevier]