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Properties of end-stage human T cells defined by CD45RA re-expression

Authors :
Henson, Sian M
Riddell, Natalie E
Akbar, Arne N
Source :
Current Opinion in Immunology. Aug2012, Vol. 24 Issue 4, p476-481. 6p.
Publication Year :
2012

Abstract

Persistent viral infections, inflammatory syndromes and ageing all induce the accumulation of highly differentiated CD45RA re-expressing memory T cells. These cells increase during ageing, especially in individuals who are infected with cytomegalovirus (CMV). These cells have decreased proliferative capacity, increased activation of senescence signalling pathways and greater susceptibility to apoptosis in vitro. However these cells are capable of multiple effector functions and thus bear all the hallmarks of short-lived effector T cells. This indicates that senescence signalling may govern the unique characteristics of effector T cells. In this article, we address the functional and migratory properties of these T cells and mechanisms that are involved in their generation. Finally we assess the potential for manipulation of their activity and whether this may improve immune function during ageing. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09527915
Volume :
24
Issue :
4
Database :
Academic Search Index
Journal :
Current Opinion in Immunology
Publication Type :
Academic Journal
Accession number :
79111382
Full Text :
https://doi.org/10.1016/j.coi.2012.04.001