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Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale.
- Source :
-
Molecules . Aug2012, Vol. 17 Issue 8, p8928-8937. 10p. 1 Diagram, 2 Charts. - Publication Year :
- 2012
-
Abstract
- In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol (1). Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol (13) and [6]-shogaol (17) exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol (15) inhibited the Ca2+-dependent contractions in high K+ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GINGER
*ZINGIBER
*SHOGAOL
*PLATELET aggregation inhibitors
*COOKING
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 17
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 79468417
- Full Text :
- https://doi.org/10.3390/molecules17088928