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Phenolics from Phaleria nisidai with Estrogenic Activity.
- Source :
-
Records of Natural Products . Jul-Sep2012, Vol. 6 Issue 3, p296-300. 5p. - Publication Year :
- 2012
-
Abstract
- The methanol extract of P. nisidai leaves yielded a benzophenone rhamnoside, iriflophenone 2-O-α- L-rhamnopyranoside (1) in addition to genkwanin 5-O-β-D-primeveroside (2) and mangiferin (3). The isolated compounds as well as the derived aglycones of 1 and 2 assigned as compounds 4 and 5, respectively, were tested for their estrogenic activity on ERα using an estrogen receptor competitive binding screen. Compounds 1, 4 and 5 showed almost the same binding ability to ERα with IC50 of 630 µM, 700 µM and 800 µM, respectively. Virtual docking with ERα revealed that compound 1, 4 and 5 strongly hydrogen bond with amino acids Glu353, Arg349, Gly521 and His524, in the estrogen receptor ligand binding domain, similar to that of mammalian estrogen 17β-estradiol. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13076167
- Volume :
- 6
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Records of Natural Products
- Publication Type :
- Academic Journal
- Accession number :
- 79567032