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Microwave-Mediated Synthesis of an Arylboronate Library.
- Source :
-
ACS Combinatorial Science . Jan/Feb2011, Vol. 13 Issue 1, p24-31. 8p. - Publication Year :
- 2011
-
Abstract
- A series of aryiboronates has befell synlhesizeil from the reaction of 2-{2-, (3-, or (4-(bramomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-diaxabarolane 1 {1-3} respectively with a range of N-, S-, and O-nucleophiles, using microwave-medialed chemistry. For the synthesis of N- and S-substituted boronates, a supported base, PS-NMM, was With O-nucleophiles, a mixture of tetrabutylammonium bromide, potassium carbonate, and sodium hydroxide was employed. The resulting aminomethyl, mercaptomethyl, or alkoxy-phenoxymethyl-arylboronates were subjected lo microwave-mediated Suzuki Miyanra cuuphng reactions to afford a range of biaryls in moderate to good yields. The X-ray structures of five boronates were determined. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21568952
- Volume :
- 13
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- ACS Combinatorial Science
- Publication Type :
- Academic Journal
- Accession number :
- 79653202
- Full Text :
- https://doi.org/10.1021/co100011g