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Cerium Ammonium Nitrate-Catalyzed Multicomponent Reaction for Efficient Synthesis of Functionalized Tetrahydropyridines.
- Source :
-
ACS Combinatorial Science . Mar/Apr2011, Vol. 13 Issue 2, p181-185. 5p. - Publication Year :
- 2011
-
Abstract
- A highly atom-economic one-pot synthesis of functionalized tetrahydropyridines by a multicomponent condensation reaction of β-keto ester, two equivalents of aromatic aldehyde, and two equivalents of amine in the presence of a catalytic amount of cerium ammonium nitrate (CAN) is reported. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate to good yields at room temperature. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHEMICAL reactions
*AMMONIUM nitrate
*NITRATES
*PIPERIDINE
*CERIUM
Subjects
Details
- Language :
- English
- ISSN :
- 21568952
- Volume :
- 13
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- ACS Combinatorial Science
- Publication Type :
- Academic Journal
- Accession number :
- 79653243
- Full Text :
- https://doi.org/10.1021/co100055x