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Synthesis of Polysubstituted 2-Piperidinones via a Michael Addition/ Nitro-Mannich/Lactamization Cascade.
- Source :
-
ACS Combinatorial Science . Jun2012, Vol. 14 Issue 6, p366-371. 6p. - Publication Year :
- 2012
-
Abstract
- An efficient and practical method has been developed for the diversity-oriented synthesis of polysubstituted 2-piperidinones via four-component reaction between substituted nitrostyrenes, aromatic aldehydes, ammonium acetate, and dialkyl malonates for the generation of a wide range of structurally interesting and pharmacologically significant compounds. It is worth mentioning that in the course of this reaction, the formation of products was highly stereoselective. Two differently stereochemical classes of polysubstituted 2-piperidinones depended on the substitutent position of aromatic aldehyde. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ORGANIC compounds
*ORGANIC chemistry
*CARBON compounds
*OXO compounds
*KETENES
Subjects
Details
- Language :
- English
- ISSN :
- 21568952
- Volume :
- 14
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- ACS Combinatorial Science
- Publication Type :
- Academic Journal
- Accession number :
- 79653460
- Full Text :
- https://doi.org/10.1021/co300022f