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Effectiveness of 1 Dose of Influenza A (H1N1) 2009 Monovalent Vaccines in Preventing Reverse-Transcription Polymerase Chain Reaction–Confirmed H1N1 Infection Among School-Aged Children in Maine.
- Source :
-
Journal of Infectious Diseases . Oct2012, Vol. 206 Issue 7, p1059-1068. 10p. - Publication Year :
- 2012
-
Abstract
- Background. In late October 2009, school-located pandemic vaccination was initiated in Maine before or concurrent with 2009 pandemic influenza A (H1N1) virus (pH1N1) peak activity.Methods. A case–control evaluation of 2009 H1N1 vaccine effectiveness was conducted in schools in Cumberland County, Maine. A case was a child who had an acute respiratory illness during 2 November–18 December 2009, and who tested positive for pH1N1 by real-time reverse-transcription polymerase chain reaction (rRT-PCR). For each case, ≥4 event time-matched controls were sampled among classmates present in school during the study period who did not have an influenza-like illness. Vaccine effectiveness was calculated as (1 – adjusted odds ratio [aOR]) × 100%; aOR was estimated by using weighted logistic regression.Results. After adjusting for a diagnosis of asthma, 1 dose of 2009 H1N1 vaccine provided 69% protection (95% confidence interval (CI), 13–89) against rRT-PCR–confirmed H1N1 infection. Vaccine effectiveness estimates for live attenuated and inactivated vaccine were 81% (95% CI, −37 to 97), and 58% (95% CI: −39 to 87), respectively.Conclusions. One dose of monovalent pandemic vaccine provided substantial protection against pH1N1 infection among school-aged children. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 206
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 79889495
- Full Text :
- https://doi.org/10.1093/infdis/jis441