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Polymorphisms of - 174G>C and - 572G>C in the Interleukin 6 (IL-6) Gene and Coronary Heart Disease Risk: A Meta-Analysis of 27 Research Studies.
- Source :
-
PLoS ONE . Apr2012, Vol. 7 Issue 4, p1-8. 8p. - Publication Year :
- 2012
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Abstract
- Objective: Elevated serum IL-6 level is a risk factor for coronary heart disease (CHD). The 2174G>C and 2572G>C polymorphisms in the IL-6 gene have previously been shown to modulate IL-6 levels. But the association between the 2174G>C and 2572G>C polymorphisms and the risk of CHD is still unclear. A meta-analysis of all eligible studies was carried out to clarify the role of IL-6 gene polymorphisms in CHD. Methods and Results:PubMed, EMBASE, Vip, CNKI and CBM-disc were searched for eligible articles in English and Chinese that were published before October 2010. 27 studies involving 11580 patients with CHD and 17103 controls were included. A meta-analysis was performed for the included articles using the RevMan 5.0 and Stata 10.0 softwares. Overall, the 2174C allele was not significantly associated with CHD risk (ORs = 1.04, 95%CI = 0.98 to 1.10) when compared with the -174G allele in the additive model, and meta-analysis under other genetic models (dominant, recessive, CC versus GG, and GC versus GG) also did not reveal any significant association. On the contrary, the -572C allele was associated with a decreased risk of CHD when compared with the -572G allele (ORs = 0.79, 95%CI = 0.68 to 0.93). Furthermore, analyses under the recessive model (ORs = 0.69, 95% = 0.59 to 0.80) and the allele contrast model (genotype of CC versus GG, ORs = 0.49, 95% = 0.35 to 0.70) yielded similar results. However, statistical significance was not found when the meta-analysis was restricted to studies focusing on European populations, studies with large sample size, and cohort studies by using subgroup analysis. Conclusions: The -174G>C polymorphism in the IL-6 gene is not significantly associated with increased risks of CHD. However, The -572G>C polymorphism may contribute to CHD development. Future investigations with better study design and large number of subjects are needed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENETIC polymorphisms
*INTERLEUKINS
*GENES
*CORONARY disease
*META-analysis
*SERUM
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 79917418
- Full Text :
- https://doi.org/10.1371/journal.pone.0034839