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Anti-cytomegalovirus effects of tricin are dependent on CXCL11
- Source :
-
Microbes & Infection . Oct2012, Vol. 14 Issue 12, p1086-1092. 7p. - Publication Year :
- 2012
-
Abstract
- Abstract: It has been reported that treatment with tricin (4′,5,7-trihydroxy-3′,5′-dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection significantly suppressed both infectious virus production and HCMV replication in the human embryonic fibroblast cell line MRC-5. In this paper, we examined the mechanisms for the anti-HCMV effects of tricin in MRC-5 cells. Exposure of fibroblasts to tricin inhibited infectious HCMV production, with concomitant decreases in levels of transcripts of the CXC chemokine IFN-inducible T cell alpha chemoattractant (I-TAC or CXCL11) gene. We also found that the transcripts of the HCMV immediate early (IE) gene and replication of HCMV were lower in CXCL11 gene-knockdown cells. These results suggest that tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. In addition, it is possible that CXCL11 is the one of the targets of tricin. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 12864579
- Volume :
- 14
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Microbes & Infection
- Publication Type :
- Academic Journal
- Accession number :
- 79989172
- Full Text :
- https://doi.org/10.1016/j.micinf.2012.05.017