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Nano-coating protects biofunctional materials
- Source :
-
Materials Today . Sep2012, Vol. 15 Issue 9, p394-404. 11p. - Publication Year :
- 2012
-
Abstract
- The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 13697021
- Volume :
- 15
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Materials Today
- Publication Type :
- Academic Journal
- Accession number :
- 82201253
- Full Text :
- https://doi.org/10.1016/S1369-7021(12)70166-9