Elevated Prevalence of 35-44 FMR1 Trinucleotide Repeats in Women With Diminished Ovarian Reserve.

The article offers information regarding Fragile X premutations associated with primary ovarian insufficiency. It states Fragile X syndrome (FXS) as a heritable form of mental retardation. It discusses the molecular cause of this abnormality which is expansion of over 200 (CGG) trinucleotide repeats within the 50-untranslated region of the fragile X mental retardation 1 gene. It also investigates a cohort analysis of infertile women diagnosed with diminished ovarian reserve (DOR).