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Selective requirement for Mediator MED23 in Ras-active lung cancer.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 10/9/2012, Vol. 109 Issue 41, p16424-16425. 2p. - Publication Year :
- 2012
-
Abstract
- The article discusses a study that was conducted to examine the role of MED23 in lung cancer. The study used viral-mediated shRNA to inhibit Med23 expression in human lung cancer cell lines in combination with a Ras mutation. The findings of the study indicate that MED23 controls the proliferation of lung cancer cells in a Ras-dependent manner. It also revealed that Med23 deficiency in fibroblasts inhibited oncogenic transformation by Ras.
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 109
- Issue :
- 41
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 82532366
- Full Text :
- https://doi.org/10.1073/pnas.1204311109