Back to Search
Start Over
Adenoidectomy in young children and serum IgG antibodies to pneumococcal surface protein A and choline binding protein A
- Source :
-
International Journal of Pediatric Otorhinolaryngology . Nov2012, Vol. 76 Issue 11, p1569-1574. 6p. - Publication Year :
- 2012
-
Abstract
- Abstract: Objective: We have previously reported that surgical removal of the nasopharyngeal adenoid in young children resulted in increased risk of nasopharyngeal colonization by pneumococci. We now investigated whether adenoidectomy influences the development of serum IgG antibodies to pneumococcal choline-binding protein A (CbpA) and pneumococcal surface protein A (PspA). Methods: Altogether 217 children aged 12–48months who had recurrent or persistent otitis media were randomized to undergo or not to undergo adenoidectomy. All the children underwent insertion of tympanostomy tubes. 166 children were followed-up for 3years. The main outcome measures were concentrations of serum IgG antibodies to CbpA and PspA three years after randomization. Nasopharyngeal colonization by pneumococci was assessed 1, 2, and 3years after randomization. Results: Adenoidectomy decreased concentrations of CbpA antibodies by ca. 25% independently of the observed increase in pneumococcal carriage (OR of log10 transformed concentrations 0.74, 95% CI 0.58–0.94, P =0.016). Concentrations of PspA antibodies were lower and they seemed not to be influenced by adenoidectomy. Conclusions: Adenoidectomy in young children causes a small but detectable impairment in the development of serum IgG antibodies to pneumococcal CbpA. The adenoid seems to have a role in augmenting systemic immunity against pneumococci. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01655876
- Volume :
- 76
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- International Journal of Pediatric Otorhinolaryngology
- Publication Type :
- Academic Journal
- Accession number :
- 82597377
- Full Text :
- https://doi.org/10.1016/j.ijporl.2012.07.013