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A Facile Solvent-Free Synthesis of Chiral Oxazolidinone Derivatives Catalyzed by MgI2 Etherate: An Approach to Enantiopure Synthesis of Linezolid.
- Source :
-
Journal of Heterocyclic Chemistry . Sep2012, Vol. 49 Issue 5, p1143-1146. 4p. 2 Diagrams, 1 Chart. - Publication Year :
- 2012
-
Abstract
- A highly efficient and stereoselective cycloaddition of aryl isocyanates with chiral oxiranes catalyzed by MgI2 etherate under solvent-free conditions was developed to prepare the chiral oxazolidinone derivatives. This methodology has been applied into the practical synthesis of antibacterial drug linezolid. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0022152X
- Volume :
- 49
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Heterocyclic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 82898165
- Full Text :
- https://doi.org/10.1002/jhet.970