Bortezomib and dexamethasone as first-line therapy for a patient with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes syndrome complicated by renal failure.

The article presents a case study of a 49-year-old man diagnosed with polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes (POEMS) syndromecaused by renal failure. The clinical examination of the patient shows his POEMS syndrome's poor prognosis. The safety and effectiveness of combined dexamethasone and bortezomib for the patients is also pointed out.