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Aortic Augmentation Index is Independently Associated With N-Terminal Pro B-type Natriuretic Peptide in Patients With Peripheral Arterial Disease.
- Source :
-
Vascular & Endovascular Surgery . Nov2012, Vol. 46 Issue 8, p648-653. 6p. - Publication Year :
- 2012
-
Abstract
- Objectives: To investigate the relationship of aortic augmentation index (AIx) with N-terminal pro B-type natriuretic peptide (NTproBNP) plasma levels in patients with peripheral arterial disease (PAD) with normal left ventricular (LV) function. Methods: Totally, 31 patients (23 males, mean age 65+7.4) with a confirmed diagnosis of PAD of the lower limbs (ankle–brachial pressure index [ABPI] <0.90 in at least 1 leg) were enrolled in this study. All patients underwent pulse wave analysis by applanation tonometry of the radial artery using the SphygmoCor system and had a measurement of plasma NTproBNP levels. Results: Patients had a mean resting ABPI of 0.62 + 0.19 and a mean AIx 32.6% + 6.9. Median (interquartile range) NTproBNP plasma level was 75 (44-210) pg/mL. In a univariate analysis which included age, brachial systolic blood pressure (BSBP), brachial diastolic blood pressure (BDBP), ejection duration index (ED%), heart rate (HR), and NTproBNP, aortic AIx was significantly associated (Spearman rho) with NTproBNP, HR, and ED% (r = .49, P = .006; r = -.72, P = .000, and r = -.42, P ¼ .02, respectively). Multivariate linear regression analysis showed that AIx was associated with NTproBNP (b ¼ 0.38, P ¼ .02) independent of gender, HR, ED%, and use of b-blockers. N-terminal pro B-type natriuretic peptide explained 8% of the variance in aortic AIx, whereas HR explained 15% of the variance. Conclusion: In patients with PAD with normal LV systolic function, AIx is independently associated with NTproBNP. Structural changes in the myocardium might occur due to increased LV afterload as a result of increased wave reflections and arterial stiffness due to atherosclerosis leading to an increase in NTproBNP plasma levels. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15385744
- Volume :
- 46
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Vascular & Endovascular Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 83226884
- Full Text :
- https://doi.org/10.1177/1538574412462634