Variable selection and estimation in generalized linear models with the seamless ${\it L}_{{\rm 0}}$.

In this paper, we propose variable selection and estimation in generalized linear models using the seamless $L_0$ (SELO) penalized likelihood approach. The SELO penalty is a smooth function that very closely resembles the discontinuous $L_0$ penalty. We develop an efficient algorithm to fit the model, and show that the SELO-GLM procedure has the oracle property in the presence of a diverging number of variables. We propose a Bayesian information criterion (BIC) to select the tuning parameter. We show that under some regularity conditions, the proposed SELO-GLM/BIC procedure consistently selects the true model. We perform simulation studies to evaluate the finite sample performance of the proposed methods. Our simulation studies show that the proposed SELO-GLM procedure has a better finite sample performance than several existing methods, especially when the number of variables is large and the signals are weak. We apply the SELO-GLM to analyze a breast cancer genetic dataset to identify the SNPs that are associated with breast cancer risk. The Canadian Journal of Statistics 40: 745-769; 2012 © 2012 Statistical Society of Canada [ABSTRACT FROM AUTHOR]