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Anticancer activity, toxicity and pharmacokinetic profile of an indanone derivative
- Source :
-
European Journal of Pharmaceutical Sciences . Dec2012, Vol. 47 Issue 5, p988-995. 8p. - Publication Year :
- 2012
-
Abstract
- Abstract: The present study describes anticancer effect of gallic acid based indanone derivative (1). Indanone 1 exhibited in vivo anticancer activity against Erhlich ascites carcinoma in Swiss albino mice by inhibiting tumor growth by 54.3% at 50mg/kg b.wt. It showed antitubulin effect by inhibiting tubulin polymerase enzyme. In cell cycle analysis, it inhibited G2/M phase and induced apoptosis. It significantly suppressed VEGF-R1, VEGF-R2 and HIF-α in human breast cancer MCF-7 cells, thus exhibiting antiangiogenic activity. In acute oral toxicity, indanone 1 was well tolerated and was found to be non-toxic up to 1000mg/kg b.wt. in Swiss albino mice. Pharmacokinetic studies in rabbits revealed rate of absorption, half life, volume of distribution with high plasma and blood clearance after i.v. administration. Indanone 1, is a safe and moderately active anticancer agent. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09280987
- Volume :
- 47
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Journal of Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 83710585
- Full Text :
- https://doi.org/10.1016/j.ejps.2012.08.013