Back to Search
Start Over
Cholinesterase inhibitory constituents from Ficus bengalensis.
- Source :
-
Journal of Asian Natural Products Research . Dec2012, Vol. 14 Issue 12, p1149-1155. 7p. 1 Diagram, 3 Charts. - Publication Year :
- 2012
-
Abstract
- Bengalensinone (22β-hydroxylup-12,20-dien-3-one; 1), a new lupane triterpene, and benganoic acid (2), a new apocarotenoid, together with lupanyl acetate, 3-acetoxy-9(11),12-ursandiene, stigmasterol, alpinumisoflavone, 4-hydroxyacetophenone, 4-hydroxybenzoic acid, 4-hydroxymellein, and p-coumeric acid were isolated from the methanolic extract of the aerial roots of Ficus bengalensis. The structures of these compounds were established by the combination of 1D NMR (1H and 13C NMR) and 2D NMR (HMQC, HMBC, and COSY) analyses, and mass spectrometry (EI-MS and HR-EI-MS), and in comparison with literature data of the related compounds. Compounds 1 and 2 displayed inhibitory potential against enzyme cholinesterase in a concentration-dependent manner with IC50 values 194.5 and 154.5 μM for acetylcholinesterase and 224.9 and 120.0 μM for butyrycholinesterase, respectively. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 14
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 83808874
- Full Text :
- https://doi.org/10.1080/10286020.2012.733702