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Total Synthesis of Aeruginosin 98B.

Authors :
Trost, Barry M.
Kaneko, Toshiyuki
Andersen, Neil G.
Tappertzhofen, Christoph
Fahr, Bruce
Source :
Journal of the American Chemical Society. 11/21/2012, Vol. 134 Issue 46, p18944-18947. 4p.
Publication Year :
2012

Abstract

The first total synthesis of aeruginosin 98B was accomplished. The key step is a highly diastereoselective Pd-catalyzed intramolecular asymmetric allylic alkylation reaction of a diastereomeric mixture of allylic carbonates that is enabled by the use of racemic phosphine ligand L1. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00027863
Volume :
134
Issue :
46
Database :
Academic Search Index
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
83882302
Full Text :
https://doi.org/10.1021/ja309947n