Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.

Authors :: Eliseo F. Castillo
Dekonenko, Alexander
Arko-Mensah, John
Mandell, Michael A.
Dupont, Nicolas
Jiang, Shanya
Delgado-Vargas, Monica
Timmins, Graham S.
Bhattacharya, Dhruva
Hongliang Yang
Hutt, Julie
Lyons, C. Rick
Dobos, Karen M.
Deretic, Vojo
Source :: Proceedings of the National Academy of Sciences of the United States of America. 11/13/2012, Vol. 109 Issue 46, p18645-18646. 2p.
Publication Year :: 2012
Abstract: The article discusses the role of autophagy against active tuberculosis. Study shows that autophagy protects against Mycobacterium tuberculosis (M. tuberculosis) infection and excessive inflammation in vivo. It states that macrophages defective for autophagy secrete proinflammatory cytokines and in a cell-autonomous fashion.

Subjects :: *AUTOPHAGY
*MYCOBACTERIUM tuberculosis
*INFLAMMATION
*MACROPHAGES
*CYTOKINES

Language :: English
ISSN :: 00278424
Volume :: 109
Issue :: 46
Database :: Academic Search Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 84040212
Full Text :: https://doi.org/10.1073/pnas.1210500109

Full Text Access

Tools