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Copper-Catalyzed Enantioselective Synthesis of Axially Chiral Allenes.
- Source :
-
Organic Letters . 12/7/2012, Vol. 14 Issue 23, p5880-5883. 4p. - Publication Year :
- 2012
-
Abstract
- A simple copper-catalyzed enantioselective synthesis of axially chiral chloroallenes from the propargylic dichlorides is reported, employing a catalytic amount of easily prepared SimplePhos ligand. Exclusive formation of the desired allenes was observed with good enantioselectivities (ee’s 62–96%). Further transformations to trisubstituted allenes or terminal alkynes with a propargylic quaternary carbon center keep a high level of enantiopurity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 14
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 84124617
- Full Text :
- https://doi.org/10.1021/ol302790e