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Direct Intermolecular Aniline Ortho-Arylation via Benzyne Intermediates.
- Source :
-
Organic Letters . 12/7/2012, Vol. 14 Issue 23, p5964-5967. 4p. - Publication Year :
- 2012
-
Abstract
- A method for direct, transition-metal-free ortho-arylation of anilines by aryl chlorides, bromides, fluorides, and triflates has been developed. This methodology provides the most direct approach to 2-arylanilines since no protecting or directing groups on nitrogen are required. The arylation is functional-group tolerant, with alkene, ether, trifluoromethyl, dimethylamino, carbonyl, chloro, and cyano functionalities tolerated. Phenylation of enantiopure binaphthyldiamine affords a product with >99% ee. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 14
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 84124638
- Full Text :
- https://doi.org/10.1021/ol302875x