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Aptamer-Capped MultifunctionalMesoporous StrontiumHydroxyapatite Nanovehicle for Cancer-Cell-Responsive Drug Deliveryand Imaging.
- Source :
-
Biomacromolecules . Dec2012, Vol. 13 Issue 12, p4257-4263. 7p. - Publication Year :
- 2012
-
Abstract
- A novel cancer-cells-triggered controlled-release gadolinium-dopedluminescent and mesoporous strontium hydroxyapatite nanorods (designatedas Gd:SrHap nanorods) system using cell-type-specific aptamers ascaps has been constructed. Aptamers behave as a dual-functional moleculethat acts as not only a lid but also a targeted molecular that canbe used in an effective way for therapeutically special cancer cells.After incubated with cancer cells, for example, MCF-7 cells, the doxorubicin-loadedand aptamer-capped Gd:SrHap nanorods (designated as Gd:SrHap-Dox-aptamer)can be internalized into MCF-7 cells, resulting in the pore openingand drug releasing. Furthermore, the high biocompatibility and biodegradabilityGd:SrHap nanorods with blue autofluorescence and paramagnetism couldserve as a good contrast agent of targeting fluorescence and magneticresonance imaging. We envision that this Gd:SrHap system could playa significant role in developing new generations of site-selective,controlled-release delivery and interactive sensory nanodevices. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15257797
- Volume :
- 13
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 84134153
- Full Text :
- https://doi.org/10.1021/bm301563q