Selection of antigen receptors in splenic marginal-zone lymphoma: further support from the analysis of the immunoglobulin light-chain gene repertoire.

Authors :: Bikos, V
Stalika, E
Baliakas, P
Darzentas, N
Davis, Z
Traverse-Glehen, A
Dagklis, A
Kanellis, G
Anagnostopoulos, A
Tsaftaris, A
Ponzoni, M
Berger, F
Felman, P
Ghia, P
Papadaki, T
Oscier, D
Belessi, C
Stamatopoulos, K
Source :: Leukemia (08876924). Dec2012, Vol. 26 Issue 12, p2567-2569. 3p. 1 Diagram, 1 Graph.
Publication Year :: 2012
Abstract: The article presents the study on the important role of the immunoglobulin light chain (IG LC) in splenic marginal-zone lymphoma (SMZL) ontogeny. It explores the IG LC gene repertoire in 107 SMZL cases to gain insight into the role of IG LCs in SMZL. The results of the study support the argument that antigen selection could be implicated in SMZL immunopathogenesis.

Subjects :: *IMMUNOGLOBULINS
*LYMPHOMAS
*ONTOGENY
*ANTIGENS
*IMMUNOPATHOLOGY

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