Direct Aza-Darzens Aziridination of N-Tosylimines with 2-Bromomalonates for the Synthesis of Highly Functionalized Donor-Acceptor Aziridines.

An approach to highly functionalized donor-acceptor aziridines by the aziridination of N-tosylimines and 2-bromomalonates in the presence of sodium hydride under mild conditions has been developed. The high-yielding reaction has a relatively broad scope and can be easily scaled up to the gram level. [ABSTRACT FROM AUTHOR]