Back to Search
Start Over
The discovery of potent and selective 4-aminothienopyridines as B-Raf kinase inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jan2013, Vol. 23 Issue 1, p66-70. 5p. - Publication Year :
- 2013
-
Abstract
- Abstract: A series of novel, potent 4-aminothienopyridine B-Raf kinase inhibitors was designed and synthesized using knowledge-based design. Compounds 5f, and 6k exhibited not only excellent potency in both enzyme assay (IC50 =5.1, 16.6nM) and cellular assay (IC50 =0.2, 0.2μM), but also had an outstanding selectivity profile against other kinases. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 23
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 84360553
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.11.020